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Seed1 Seed2 Seed3 Seed4 Seed5 Seed6 Seed7

Regulatory Interaction Maps of Arabidopsis Seed Development

The regulation of LEC1/AFL-B3 genes includes transcriptional regulation, chromatin remodeling and others. Repression of the embryonic master regulators LEC1 and FUS3 during vegetative development by the chromatin remodelling factor PKL is realized by Polycomb group protein (PcG)-mediated histone methylation (Aichinger et al. 2009). SWINGER (SWN) and EMBRYONIC FLOWER (EMF2) are under direct transcriptional control of PKL and the corresponding proteins, in complex with CURLY LEAF, trimethylate histone H3 at the critical lysine residue 27 at the LEC1 and FUS3 loci (Aichinger et al. 2009, Makarevich et al. 2006). LEC1 and PKL constitute a negative feedback loop with LEC1 enhancing the expression of the PKL gene encoding its own inhibitor (Mu et al. 2008). As subunit of SWI/SNF multi-protein complexes BRAHMA directly represses the transcription of SSP genes (Tang et al. 2008). The membrane located peptidase AMP1 and the MYB transcription factors MYB115/118 regulate LEC1 expression positively (Suzuki et al. 2008, Wang et al. 2009). The MADS transcription factor AGL15, the encoding gene of which itself is a direct target of LEC2, seems to bind the promoters of ABI3, FUS3 and LEC2 thereby establishing a positive feedback loop (Zheng et al. 2009). The VAL B3 domain proteins, the histone deacetylases HDAC6/19 and the trihelix domain protein ASIL1 act as global repressors of the embryonic program and the LEC1/AFL-B3 network (Gao et al. 2009, Suzuki et al. 2007, Tanaka et al. 2008, Tsukagoshi et al. 2005, 2007).

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